Parametric eq frequencies

Hello all. I’ve had my 650 for 6 months or so now. I was able to pull my passive xo’s out and have my diy speakers sounding great. But I am curious about something. When setting the equipment for the drivers, should you change the frequencies of the equipment depending on what driver you are making adjustments? By that I mean should I drop all the frequency settings in the eq when setting the subs to all lower frequencies and the opposite, change the eq to all higher frequencies when adjusting the tweeters? Hope that makes sense. I’ll try to explain better if need be